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Structural basis of asymmetric DNA methylation and ATP-triggered long-range diffusion by EcoP15I

NIAID Data Ecosystem2026-05-01 收录

甲基化反应机制

限制性修饰酶结构

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Structural basis of asymmetric DNA methylation and ATP-triggered long-range diffusion by EcoP15I

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创建时间：

2024-03-06

甲基化反应机制

微生物表观遗传调控

Epigenetic modifications such as DNA methylation have large effects on gene expression and genome maintenance. Helicobacter pylori, a human gastric pathogen, has a large number of DNA methyltransferas

NIAID Data Ecosystem120

Murine De Novo Methyltransferase Dnmt3a Demonstrates Strand Asymmetry and Site Preference in the Methylation of DNA In Vitro

甲基化反应机制

底物特异性

CpG methylation is involved in a wide range of biological processes in vertebrates as well as in plants and fungi. To date, three enzymes, Dnmt1, Dnmt3a, and Dnmt3b, are known to have DNA methyltransf

PubMed Central60

WP3585 - Cytosine methylation - Homo sapiens

表观遗传调控

甲基化反应机制

DNA, namely cytosine, methylation is the key event in epigentics. The degree of methylation influences gene expression and methylation disorders are known to be major causes of some diseases like Rett

NIAID Data Ecosystem30

Methylation and gene expression data from Dnmt3b+/+, Dnmt3b-/- and Dnmt3bCI/CI embryos harvested at E11.5

发育表观遗传学

甲基化反应机制

Dnmt3b is a DNA methyltransferase, an enzyme which methylates genomic DNA, contributes to genomic stability and transcriptional regulation. Inactivation of Dnmt3b in mice results in embryonic lethalit

NIAID Data Ecosystem70

Dnmt1-Independent CG Methylation Contributes to Nucleosome Positioning in Diverse Eukaryotes

甲基化反应机制

染色质结构

Dnmt1 epigenetically propagates symmetrical CG methylation in many eukaryotes. Their genomes are typically depleted of CG dinucleotides because of imperfect repair of deaminated methylcytosines. Here,

NIAID Data Ecosystem40

Structural basis of asymmetric DNA methylation and ATP-triggered long-range diffusion by EcoP15I

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