Chagas’ disease is caused by Trypanosoma cruzi, a protozoan transmitted to humans by blood-feeding insects, blood transfusion or congenitally. Previous research led us to discover a parasite proline r
As one of the largest protein families, protein kinases (PKs) regulate nearly all processes within the cell and are considered important drug targets. Much research has been conducted on inhibitors fo
From those compounds exhibiting IC50 50 Giardia trophozoites in the benchmark screening (see in Fig 3) exact dose responses were determined (values highlighted in green). PDE activity assays were done
BackgroundHuman African Trypanosomiasis (HAT) also called sleeping sickness is an infectious disease in humans caused by an extracellular protozoan parasite. The disease, if left untreated, results in
