Binding mode of a cationic porphyrin to parallel and antiparallel thrombin binding aptamer G-quadruplex
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The spectral properties of <i>meso</i>-tetrakis (<i>N</i>-methylpyridinium-4-yl)porphyrin (TMPyP) in the presence of parallel and antiparallel G-quadruplexes formed from a thrombin-binding aptamer G-quadruplex (5′-G<sub>3</sub>T<sub>2</sub>G<sub>3</sub>TGTG<sub>3</sub>T<sub>2</sub>G<sub>3</sub>) were investigated in this study. Red shift and hypochromism in the Soret absorption band of TMPyP were observed after binding to both parallel and antiparallel G-quadruplexes. The extent of changes in the absorption spectra were similar for both conformers. No circular dichroism spectrum was induced in the Soret region for both parallel and antiparallel G-quadruplexes. This is suggest that there is no or very weak interaction between electric transitions of nucleobases and porphyrin molecule. The accessibility of the neutral quencher I<sub>2</sub> to the G-quadruplex-bound TMPyP was similar for both parallel and antiparallel G-quadruplexes. All these observations suggest that TMPyP was bound at the outside of the quadruplexes, and conceivably interacted with the phosphate group via a weak electrostatic interaction. Communicated by Ramaswamy H. Sarma
提供机构：
Taylor & Francis
创建时间：
2019-08-08
