Complete Sankey diagram

Sankey diagram showing the clustering of all ninety-two combinations On the left x axis, the first author of the included study is depicted. Each curved line represents a study. The width of the curves is proportional to the number of patients with NVO and its synonyms included, reaching the middle x axis (year of publication). From years of publication axis, until the right x axis (showing the possible combinations of diagnostic criteria), curves are not anymore proportional to the number of patients, to improve readability. Diagnostic criteria combination data legend: 1- Clinical features (symptoms, signs, patient history) 2- Inflammatory biomarkers (CRP; ESR; WBC) 3- MRI (with or without contrast medium) 4- Other imaging techniques (plain films, CT scan, PET/CT, scintigraphy or other nuclear medicine technique) 5- Microbiological evidence from blood cultures 6- Microbiological evidence from spinal cultures 7- Histopathology 8- Clinical improvement after antimicrobial treatment桑基图（Sankey diagram）展示了全部92种组合的聚类分布。左侧X轴标注纳入研究的第一作者，每条曲线代表一项研究。曲线宽度与纳入的NVO及其同义病症患者的例数呈正比，延伸至中间X轴（发表年份）。为提升可读性，自发表年份轴至右侧X轴（展示诊断标准的各类可能组合）的曲线，其宽度不再与患者例数呈正比。诊断标准组合数据图例：1. 临床特征（症状、体征、患者病史）；2. 炎症生物标志物（CRP、ESR、WBC）；3. 磁共振成像（MRI，含或不含造影剂）；4. 其他影像学技术（平片、CT扫描、PET/CT、闪烁扫描或其他核医学技术）；5. 血培养微生物学证据；6. 脊柱培养微生物学证据；7. 组织病理学；8. 抗菌药物治疗后的临床症状改善。