Transcriptomic analysis of human laryngeal carcinoma cell line LIU-LSC-1 with depletion of ITGA5

Recent studies have shown that integrins have a promotive effect on cancer. In our clinical work, we found that integrin subunit alpha 5 (ITGA5) was highly expressed in laryngeal cancer tissues. Further in vitro functional assays showed that ITGA5 promotes proliferation, migration and metastasis of laryngeal cancer cells. To investigate how ITGA5 exerts these functions and its downstream regulatory genes, we knocked down ITGA5 in the laryngeal cancer cell line LIU-LSC-1 and sequenced the transcriptome of wild-type and ITGA5 knockdown cells. Overall design: Retinal mRNA profiles of wild type (WT) and ITGA5-/-LIU-LSC-1 cells