Data from: Sialendoscopy enhances salivary gland function in Sjögren’s syndrome: a 6 month follow-up, randomized and controlled, single blind study

Objectives: To assess the effect of sialendoscopy of the major salivary glands on salivary flow and xerostomia in patients with Sjögren’s syndrome (SS). Methods: Forty nine SS patients were randomly assigned to a control group (n=15) and two intervention groups: irrigation of the major glands with saline (n=16) or with saline followed by triamcinolone acetonide (TA) in saline (n=18). Unstimulated whole saliva flow (UWS), chewing stimulated whole saliva flow (SWS), citric-acid stimulated parotid flow (SPF), Clinical Oral Dryness Score (CODS), Xerostomia Inventory score (XI), and EULAR SS Patient Reported Index (ESSPRI) were obtained 1 week (T0) before, and 1(T1), 8(T8), 16(T16), and 24(T24) weeks after sialendoscopy. Results: Median baseline UWS, SWS and SPF scores were, respectively, 0.14, 0.46, and 0.22mL/min. After intervention, significant increases in UWS and SWS were observed in the saline group (at T8 (p=0.013) and T24 (p=0.004)) and the saline/TA group (at T24 (p=0.03) and T=16 (p=0.035). SPF was increased significantly in the saline/TA group at T24 (p=0.03). XI scores declined after sialendoscopy in both intervention groups. Compared to the control group, CODS, XI, and ESSPRI improved in the intervention groups. UWS, SWS, and SPF were higher in the intervention groups compared to the control group, but these differences were not significant except for SPF in the saline/TA group at T24 (p=0.005). Conclusions: Irrigation of the major salivary glands in SS patients enhances salivary flow and reduces xerostomia up to 6 months after sialendoscopy.研究目的：评估大唾液腺涎腺内镜检查（sialendoscopy）对舍格伦综合征（Sjögren’s syndrome, SS）患者唾液分泌流量及口干症（xerostomia）的影响。 研究方法：将49名舍格伦综合征患者随机分为对照组（n=15）与两个干预组：单纯生理盐水冲洗大唾液腺组（n=16），以及生理盐水联合曲安奈德（triamcinolone acetonide, TA）生理盐水溶液冲洗组（n=18）。分别于涎腺内镜检查前1周（T0），以及检查后1周（T1）、8周（T8）、16周（T16）、24周（T24）采集以下指标：非刺激性全唾液流量（Unstimulated whole saliva flow, UWS）、咀嚼刺激性全唾液流量（Chewing stimulated whole saliva flow, SWS）、柠檬酸刺激腮腺唾液流量（Citric-acid stimulated parotid flow, SPF）、临床口腔干燥评分（Clinical Oral Dryness Score, CODS）、口干量表评分（Xerostomia Inventory score, XI）及欧洲抗风湿病联盟舍格伦综合征患者报告指数（EULAR SS Patient Reported Index, ESSPRI）。 研究结果：基线时非刺激性全唾液流量、咀嚼刺激性全唾液流量及柠檬酸刺激腮腺唾液流量的中位数分别为0.14、0.46及0.22mL/min。干预后，生理盐水组在T8（p=0.013）及T24（p=0.004）时非刺激性全唾液流量与咀嚼刺激性全唾液流量均出现显著升高；生理盐水/曲安奈德组在T24（p=0.03）及T16（p=0.035）时上述两项指标亦显著升高。生理盐水/曲安奈德组在T24时柠檬酸刺激腮腺唾液流量显著升高（p=0.03）。两个干预组的口干量表评分在涎腺内镜检查后均有所下降。与对照组相比，干预组的临床口腔干燥评分、口干量表评分及欧洲抗风湿病联盟舍格伦综合征患者报告指数均得到改善。干预组的非刺激性全唾液流量、咀嚼刺激性全唾液流量及柠檬酸刺激腮腺唾液流量均高于对照组，但除生理盐水/曲安奈德组在T24时的柠檬酸刺激腮腺唾液流量（p=0.005）外，其余差异均无统计学意义。 研究结论：对舍格伦综合征患者行大唾液腺冲洗联合涎腺内镜检查，可提升唾液分泌流量并缓解口干症状，该效果可持续至检查后6个月。