Summary of immunohistochemistry staining (IMMUNO HIS) and mutations found in the p53 gene in tumor samples from patients not pre-treated with chemotherapy prior to surgery (A) and neo-adjuvant treated patients (B).

Mutations are designated with the wild-type amino acid, followed by the codon and the substituted amino acid. The Activity (i.e., functional consequence) of each mutation was determined by using the IARC (International Agency for Research on Cancer) TP 53 Mutation Database (http://www-p53.iarc.fr/) and scored as follows: Functional (change in aa sequence with equivalent function), Silent (no change in amino acid) or LOF (change in aa sequence with loss of function) (nd = not determined).