Estimated environmental risk score (ERS) weights for environmental pollutants selected for each phenotype.

HDL, high-density lipoprotein cholesterol; LDL, low-density lipoprotein cholesterol; PAHs, polycyclic aromatic hydrocarbons; PFCs, perfluorinated compounds; PCBs, polychlorinated biphenyls; TCDD, tetrachlorodibenzodioxin; PnCDF, pentachlorodibenzofuran; HxCDF, hexachlorodibenzofuran; HpCDF, heptachlorodibenzofuran; PnCB, pentachlorobiphenyl; HxCB, hexachlorobiphenyl; DDT, dichlorodiphenyltrichloroethane. All models were adjusted for age, gender, race/ethnicity, education, BMI and phenotype-specific nutrients shown in Table S3. aWeights were estimated using the training data (n = 11586). bERS constructed with coefficient estimates from single-pollutant models as weights. cERS constructed with coefficient estimates from multi-pollutant models as weights. #p-value<0.001, *0.001≤p-value<0.01, and ∧0.01≤p-value<0.05.