Self [3 + 4] Cycloadditions of Isatin N,N′‑Cyclic Azomethine Imine 1,3-Dipole with N‑(o‑Chloromethyl)aryl Amides
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A [3 + 4] annulation of isatin N,N′-cyclic azomethine imine 1,3-dipole 1 with in situ-generated aza-oQMs has been established for the synthesis of spirooxindole seven-membered scaffolds. These highly functionalized scaffolds were assembled in moderate to good yields (up to 96% yield). The novel spirooxindole scaffolds displayed moderate antitumor activities, which represented promising lead compounds for antitumor drug discovery.
创建时间：
2018-06-10
