Gut microbial composition associated with risk of premature aging in women with yin-deficiency constitution

Yin-deficiency constitution (YinDC) refers to a traditional Chinese medicine concept, characterized by an imbalance state that includes an imbalance in the gut microbiota, resulting from a relative deficiency of Yin fluids within the body. In recent years, it has become apparent that the composition and structure of the gut microbiota play a significant role in the aging process. The imbalance of gut microbiota in YinDC may accelerate the aging process. However, the specific gut microbiota compositions involved in the YinDC premature aging process remain unknown. Here, we conducted a study to analyze the association between the gut microbiota and premature aging in YinDC women. At the phylum level, Cyanobacteria and Synerobacteria were found exclusively in the YinDC group. At the genus level, Bacteroides, Bifidobacterium, Haemophilus, Alistipes, and Dialister were more abundant in the YinDC group. Bilophila, Eubacterium, and Aeromonas were the most significant indicators influencing YinDC premature aging. Thus, this study demonstrated that the gut microbiota was associated with premature aging in women with YinDC, potentially providing preliminary evidence and guidance for personalized anti-aging strategies.