Crystal structure of the T877A androgen receptor ligand binding domain in complex with (S)-N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanonaphthalen-1-yloxy)-2-hydroxy-2-methylpropanamide

Crystal structure of the T877A androgen receptor ligand binding domain in complex with (S)-N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanonaphthalen-1-yloxy)-2-hydroxy-2-methylpropanamide Descriptor: (2S)-3-[(4-cyanonaphthalen-1-yl)oxy]-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide, Androgen receptor Authors: Bohl, C.E, Duke, C.B, Jones, A, Dalton, J.T, Miller, D.D. Deposit date: 2011-04-19 Release date: 2011-05-04 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Unexpected binding orientation of bulky-B-ring anti-androgens and implications for future drug targets. J.Med.Chem., 54, 2011

T877A雄激素受体（androgen receptor）配体结合域与(S)-N-(4-氰基-3-(三氟甲基)苯基)-3-(4-氰基萘-1-基氧基)-2-羟基-2-甲基丙酰胺形成复合物的晶体结构。描述符：(2S)-3-[(4-氰基萘-1-基)氧基]-N-[4-氰基-3-(三氟甲基)苯基]-2-羟基-2-甲基丙酰胺，雄激素受体。作者：Bohl, C.E、Duke, C.B、Jones, A、Dalton, J.T、Miller, D.D.。沉积日期：2011-04-19；发布日期：2011-05-04；最后修改日期：2023-09-13。实验方法：X射线衍射（分辨率1.7埃）。引用文献：《大体积B环抗雄激素的意外结合取向及其对未来药物靶点的启示》，《J.Med.Chem.》，54卷，2011年。