norven

The data presented herein relates to the article entitled "Effects of norfluoxetine and venlafaxine in zebrafish larvae: molecular data" by Rodrigues et al., submitted to Data In Brief. The file contains raw data corresponding to expression of several zebrafish genes related to mode of action of psychoactive compounds acting upon serotonergic or/and noradrenergic neurotransmission. Zebrafish embryos were exposed to concentrations of norfluoxetine (0.64 to 400 ng/L), venlafaxine (16 to 10000 ng/L) or their combination (3.2 ng/L norfluoxetine + 2000 ng/L venlafaxine) over 80 hpf (hours post-fertilisation). At the end of the exposure, larvae were collected for quantification of the expression of 34 genes. Gene expression was evaluated by qPCR (SYBRGreen). Details on exposure conditions, gene sequences, primers employed and assay conditions are provided in the submitted article. The work was supported by funding EU and FCT/UEFISCDI/FORMAS funding through project REWATER (ERA-NET Cofund WaterWorks2015, Water JPI) and by national funds through FCT (Portuguese Foundation for the Science and Technology) within the scope of UIDB/04423/2020 and UIDP/04423/2020. PR was supported by a PhD fellowship (SFRH/BD/134518/2017) from FCT.本数据集关联Rodrigues等人提交至《数据简报》（Data In Brief）的题为《斑马鱼幼虫中去甲氟西汀与文拉法辛的作用效应：分子数据》（Effects of norfluoxetine and venlafaxine in zebrafish larvae: molecular data）的研究文章。该文件包含与作用于血清素能或/和去甲肾上腺素能神经传递的精神活性化合物作用模式相关的多种斑马鱼基因的原始表达数据。研究将斑马鱼胚胎暴露于不同浓度的去甲氟西汀（0.64~400 ng/L）、文拉法辛（16~10000 ng/L），或二者联合暴露组（3.2 ng/L去甲氟西汀+2000 ng/L文拉法辛），直至受精后80小时（80 hpf）。暴露结束后，收集幼虫以定量分析34个基因的表达水平。基因表达通过qPCR（SYBRGreen法）进行评估。暴露条件、基因序列、所用引物及实验条件的详细信息均见于已提交的研究文章。 本研究获欧盟及FCT/UEFISCDI/FORMAS资助，通过REWATER项目（ERA-NET Cofund WaterWorks2015，水联合计划（Water JPI））开展，并获葡萄牙科学技术基金会（Fundação para a Ciência e a Tecnologia，简称FCT）的国家资金支持，项目编号为UIDB/04423/2020与UIDP/04423/2020。PR获FCT颁发的博士奖学金（SFRH/BD/134518/2017）资助。