Comparison of WT-PR computed binding energies.

aTable 1.bTable 1 plus Table S5 in File S1.cTable S6 in File S1.Energies were computed with the standard RosettaDock energy function, as described in [15] and with the FMO re-evaluation. A Mann-Whitney's U test probability was evaluated by comparing the binding energies of the set of endogenous peptide against the non-cleavable and the entire set of cleavable peptides against the non-cleavable. The FMO based binding energies are more clear in discriminating cleavable and non cleavable peptides than the Rosetta based ones.