Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ETHYL-5-[(3R)-3-[2-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1063)

Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ETHYL-5-[(3R)-3-[2-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1063) Descriptor: 6-ethyl-5-{(3S)-3-[2-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine, Dihydrofolate reductase, GLYCEROL, ... Authors: Reeve, S.M, Wright, D.L. Deposit date: 2018-12-13 Release date: 2019-09-25 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.243 Å) Cite: Structure-Guided In Vitro to In Vivo Pharmacokinetic Optimization of Propargyl-Linked Antifolates. Drug Metab.Dispos., 47, 2019

金黄色葡萄球菌（Staphylococcus aureus）二氢叶酸还原酶（Dihydrofolate Reductase）与烟酰胺腺嘌呤二核苷酸磷酸（还原型，NADPH）及6-乙基-5-[(3R)-3-[2-甲氧基-5-(吡啶-4-基)苯基]丁-1-炔-1-基]嘧啶-2,4-二胺（UCP1063）的复合物。描述项：6-乙基-5-{(3S)-3-[2-甲氧基-5-(吡啶-4-基)苯基]丁-1-炔-1-基}嘧啶-2,4-二胺、二氢叶酸还原酶、甘油（GLYCEROL）等。作者：Reeve, S.M.、Wright, D.L.。提交日期：2018-12-13；发布日期：2019-09-25；最后修改日期：2023-10-11。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.243埃。引用文献：《结构导向的炔丙基连接抗叶酸剂体外到体内药代动力学优化》，《药物代谢与处置》（Drug Metab. Dispos.），第47卷，2019年。