DE statistics.

A) Histogram of log2 fold changes for DE genes showing that 54.8% of the DE genes are overexpressed in HD cases. B) Fraction of up vs down regulated genes across the gene list ranked by significance. Top and bottom plots are top 500 and remaining genes, respectively. Sliding windows lines plot the fraction up vs down in the 100 gene window of greater rank than the x coordinate. This plot shows that the most highly differentially expressed genes are predominantly over-expressed in HD relative to control BA9. C) Pie chart shows proportions of biotypes for DE genes according to Ensembl. Protein coding genes are over-represented among the DE genes. D) Normalized counts for all samples in HD and control for top ten significant genes. Rows are normalized for visualization such that the highest count is equal to 1. These genes are almost exclusively expressed in HD cases.