LSD1-CoREST in complex with AW2, short soaking

LSD1-CoREST in complex with AW2, short soaking Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (2R,3S,4S)-5-[(1R,3S,3aS,13R)-3-([1,1'-biphenyl]-4-yl)-1-hydroxy-10,11-dimethyl-4,6-dioxo-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate (non-preferred name) Authors: Caroli, J, Mattevi, A. Deposit date: 2022-11-09 Release date: 2024-06-12 Last modified: 2025-06-25 Method: X-RAY DIFFRACTION (3 Å) Cite: Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance. Nat Commun, 16, 2025

与AW2结合的LSD1-CoREST复合物（短浸泡处理）
描述符：赖氨酸特异性组蛋白去甲基化酶1A（Lysine-specific histone demethylase 1A）、REST辅阻遏物1（REST corepressor 1）、[(2R,3S,4R,5R)-5-(6-氨基-9H-嘌呤-9-基)-3,4-二羟基四氢呋喃-2-基]甲基 (2R,3S,4S)-5-[(1R,3S,3aS,13R)-3-([1,1'-联苯]-4-基)-1-羟基-10,11-二甲基-4,6-二氧代-2,3,5,6-四氢-1H-苯并[g]吡咯并[2,1-e]蝶啶-8(4H)-基]-2,3,4-三羟基戊基二氢二磷酸（非推荐名称）
作者：Caroli, J、Mattevi, A.
保藏日期：2022-11-09
发布日期：2024-06-12
最后修改日期：2025-06-25
实验方法：X射线衍射（分辨率3 Å）
引用文献：《共价加合物Grob碎裂揭示LSD1去甲基化酶特异性抑制剂的作用机制与耐药性》，《自然-通讯》，16卷，2025年