Functional MRI of emotional memory in adolescent depression: Encode.Trial gt Baseline.AllWords.UnMedSubs.Corr Age

<p>FSL5.0</p>

[](https://neurovault.org/images/14643)

### Collection description

<p>Introduction: Major Depressive Disorder (MDD) is a leading cause of disease burden worldwide. Mood-congruent biases in memory tasks are frequently reported in MDD patients, with facilitated memory for negative stimuli. Most functional MRI studies to date have examined the neural correlates of these biases in depressed adults, with fewer studies in adolescents with MDD. Investigation of MDD in adolescence may aid greater understanding of the aetiology and development of the disorder. <br>Methods: Cognitive biases were investigated in 56 MDD patients aged 11-17 years and a matched group of 30 healthy control participants with a self-referential memory task. Behavioural performance and BOLD fMRI data were collected during both encoding and retrieval stages. <br>Results: The neural response to encoding in adolescents with MDD was found to differ significantly from controls. Additionally, neural responses during encoding and retrieval showed differential relationships with age between patient and control groups, specifically in medial, temporal, and prefrontal regions. <br>Conclusions: These findings suggest that during adolescence neurophysiological activity associated with emotional memory differs in those with depression compared to controls and may be age sensitive. </p>

###Subject species

homo sapiens

### Map type

Other

{'introduction': '重度抑郁症（MDD）是全球疾病负担的主要原因之一。在MDD患者中，情绪一致的记忆偏差现象屡见不鲜，他们对消极刺激的记忆能力得到增强。迄今为止，大多数功能性磁共振成像（fMRI）研究都探讨了抑郁成年人在这些偏差方面的神经相关性，而在青少年MDD患者中的研究相对较少。对青少年MDD的研究可能有助于更深入地理解该疾病的病因和发展过程。', 'methods': '本研究调查了56名11-17岁的MDD患者和30名匹配的健康对照参与者的认知偏差。在自我参照的记忆任务中，收集了编码和回忆阶段的行为表现和血氧水平依赖性（BOLD）fMRI数据。', 'results': '研究发现，MDD青少年的编码过程中的神经反应与对照参与者存在显著差异。此外，编码和回忆过程中的神经反应与患者组和对照组之间的年龄差异显示出不同的相关性，特别是在内侧、颞叶和前额叶区域。', 'conclusions': '这些发现表明，在青少年期，与情绪记忆相关的神经生理活动在抑郁症患者与对照参与者之间存在差异，且可能具有年龄敏感性。'}