Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms

ChEBI2014-03-12 更新2026-07-21 收录

骨髓增殖性肿瘤

造血干细胞微环境

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Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms

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2014-03-12

Gene expression profile of murine bone marrow endosteal populations (2)

造血干细胞微环境

滑膜与骨膜细胞基因表达

A subset of osteoblasts functions as a key component of the hematopoietic stem cell niche. But it is still unclear that the precise cellular and molecular contribution of endosteal cell populations on

NIAID Data Ecosystem140

Physical interaction between mutant calreticulin and the thrombopoietin receptor is required for transformation of hematopoietic cells. Mus musculus

骨髓增殖性肿瘤

癌症信号通路

Somatic mutations in calreticulin (CALR) are present in approximately 40% of patients with myeloproliferative neoplasms (MPN). However, the mechanism by which mutant CALR is oncogenic is unknown. Here

NIAID Data Ecosystem70

Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)(p12;q12)

骨髓增殖性肿瘤

FGFR1-FIM融合基因

Chromosome 8p11–12 is the site of a recurrent breakpoint in a myeloproliferative disorder that involves lymphoid (T- or B-cell), myeloid hyperplasia and eosinophilia, and evolves toward acute leukemia

PubMed Central1998-05-12 更新40

Early B Cell Factor 2 Regulates Hematopoietic Stem Cell Homeostasis in a Cell-Nonautonomous Manner. Mus musculus

造血干细胞微环境

转录因子调控

Hematopoiesis requires the interaction of hematopoietic stem cells (HSCs) with various stromal microenvironments. Here, we examine the role of early B cell factor 2 (Ebf2), a transcription factor expr

NIAID Data Ecosystem80

RNA-seq analysis of bone marrow peri-vascular stromal cells. Mus musculus

造血干细胞微环境

周血管基质细胞转录组

Fate decisions of haematopoietic stem cells (HSCs) to self-renew or differentiate in response to various demands are finely tuned by specialized microenvironments called “niches” in the bone marrow. R

NIAID Data Ecosystem50

Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms

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