Effect of depletion of FOXO3A on gene expression of U-937 cells. Effect of depletion of FOXO3A on gene expression of U-937 cells

To explore the underlying molecular mechanisms of FOXO3A-regulated AML cell function To determine the impact of FOXO3A deficiency on AML cells, we generated knock-out (KO) cells of FOXO3A using small guide RNAs (sgRNAs) Overall design: Comparative gene expression profiling analysis of RNA-seq data for U-937 cells and its KO derivatives (sgFOXO3A).