Elevated translocator protein in skull bone marrow is linked to human chronic pain

README ====== Dataset title ------------- Elevated translocator protein in skull bone marrow is linked to human chronic pain Description ----------- This dataset contains multimodal neuroimaging data acquired from patients with chronic low back pain, patients with knee osteoarthritis, and healthy controls. Data include positron emission tomography (PET) with the radiotracer [11C]PBR28 and structural MRI (T1-weighted). Participants ------------ Participants included patients with chronic low back pain, patients with knee osteoarthritis, and healthy control subjects. Imaging modalities ------------------ - PET: [11C]PBR28, a radiotracer that binds the 18 kDa translocator protein (TSPO), a marker of neuroinflammation/immune cell activation. Acquired as a 90-minute dynamic scan on a Siemens Biograph mMR PET/MR scanner; static SUV images were reconstructed from the 60-90 minute post-injection window. - Structural MRI: T1-weighted MPRAGE, acquired on the same Siemens Biograph mMR scanner at 3T, coregistered to the PET image. De-identification ----------------- All structural MRI images (T1w) were defaced prior to public release to remove facial features and protect participant privacy. Study design ------------ This is an observational, cross-sectional study. No experimental intervention or task was performed during image acquisition. Funding ------- This work was supported by the National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, under awards 1R01NS094306-01A1 and 1R01NS095937-01A1, and by the National Institute on Drug Abuse (NIDA) under award 5R01DA053316-05. Notes ----- The dataset is organized according to the Brain Imaging Data Structure (BIDS) specification.