Modeled net infectivities and effect sizes of antimalarial treatment.

Abbreviations: JE, Jeffery-Eyles; CG, Carter & Graves; CQ, chloroquine; ACT, artemisinin-based combination therapy; PQ, primaquine. Net infectivity indicates the area under the infectivity curve, a measure of the malaria transmission potential. This value indicates the mean number of days that an individual is infectious for a mosquito vector. Fold-reductions indicate the fold changes in net infectivity either post-treatment or pre- and post-treatment. The latter change is known as the ‘effect size’ of an intervention. The modeled parameterizations for CQ are mild, moderate 1, moderate 2, and strong (increasing the assumed gametocytemic potency of treatment). For ACT the simulated gametocytocidal components were mild, moderate, and strong. For ACT+PQ the parameterizations are moderate and strong; the numbers in brackets indicate the treatment day on which the PQ component was administered.