mRNA-Seq reads aligned to HTT in hg38/GENCODEv21
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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Despite 20 years since its discovery, the gene responsible for Huntingtonâs Disease, HTT, has still not had its function or transcriptional profile completely characterized. In response to a recent report by Ruzo et al. of several novel splice forms of HTT in human embryonic stem cell lines, we have analyzed a set of mRNA sequencing datasets from post mortem human brain from Huntingtonâs disease, Parkinsonâs disease, and neurologically normal control subjects to evaluate support for previously observed and to identify novel splice patterns. A custom analysis pipeline produced supporting evidence for some of the results reported by two previous studies of alternative isoforms as well as identifying previously unreported splice patterns. All of the alternative splice patterns were of relatively low abundance compared to the canonical splice form.
提供机构：
Boston University Medical School
创建时间：
2022-02-20
