Calcium and vitamin D supplementation on bone structural properties in peripubertal female identical twins

A randomised controlled trial was used in assessing the impact of 6 months of daily calcium and vitamin-D supplementation on trabecular and cortical bone acquisition at distal tibial and radial sites using peripheral quantitative computed tomography (pQCT). Daily supplementation was associated with increased bone density and bone strength at the distal tibia and radius. Twenty pairs of peripubertal female identical twins, aged 9 to 13 years, were randomly assigned to receive either 800 mg of calcium and 400 IU of vitamin D3, or a matched placebo. Bone structural properties at the distal tibia and distal radius were acquired at baseline and 6 months. pQCT data for all three stages of the trial. Data can be exported to SPSS or MS Excel. Statistical analyses available in SPSS format. The Australian Twin Registry arranged contact with the twins. USANA supplied the supplements.

本研究采用随机对照试验设计，评估为期6个月的每日钙与维生素D补充干预对胫骨远端和桡骨远端部位小梁骨与皮质骨获得情况的影响，检测手段采用外周定量计算机断层扫描（peripheral quantitative computed tomography, pQCT）。每日补充该制剂可提升胫骨远端与桡骨远端的骨密度及骨强度。本研究共纳入20对年龄介于9至13岁的青春前期女性同卵双胞胎，将其随机分配至两组，分别接受800mg钙与400IU维生素D3补充剂，或匹配的安慰剂。分别于基线及干预6个月后，采集受试者胫骨远端与桡骨远端的骨结构特性数据。本试验全部三个阶段的外周定量计算机断层扫描（pQCT）数据均可导出至SPSS或MS Excel。配套的统计分析程序以SPSS格式提供。澳大利亚双胞胎登记处（Australian Twin Registry）负责协调与该批双胞胎受试者的联络工作。USANA公司提供了本次试验所用的补充制剂。