Nfs1

Predicted to enable cysteine desulfurase activity and protein homodimerization activity. Involved in [4Fe-4S] cluster assembly and iron incorporation into metallo-sulfur cluster. Located in mitochondrial matrix and nucleus. Part of mitochondrial [2Fe-2S] assembly complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 52. Orthologous to human NFS1 (NFS1 cysteine desulfurase). [provided by Alliance of Genome Resources, Nov 2024]

预测该基因能够激活半胱氨酸脱硫酶活性和蛋白质同源二聚化活性。参与[4Fe-4S]簇组装及铁元素融入金属硫簇的过程。定位于线粒体基质及细胞核内。构成线粒体[2Fe-2S]组装复合体的一部分。在多个结构中表达，包括消化系统；中枢神经系统；泌尿生殖系统；呼吸系统；以及感觉器官。该基因的人类同源基因与联合氧化磷酸化缺陷52有关。与人类NFS1（NFS1半胱氨酸脱硫酶）同源。[由基因组资源联盟提供，2024年11月]