Purpose: This study interrogated the role of αSMA+ CAFs in a genetic moue model of metastatic colorectal cancer. Methods: αSMA+ CAFs were selectively depleted in mouse CRC model. RNA was isolated from
Tumor-host interactions play an important role in cancer initiation and progression. To investigate changes in local host factors associated with proximity to the tumor, the global gene expression pro
High-grade serous ovarian cancer (HG-SOC), characterized by very frequent mutations in TP53 gene, is a highly lethal cancer and is refractory to therapeutic strategies. In HG-SOC, the reciprocal sign