SiMPLOD v. 0.6.2 alpha

SiMPLOD is an online database which collects all the currently described natural variants as well as biochemical mutations of LH/PLOD (Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase/Lysyl-Hydroxylase). The SiMPLOD interface allows localization of the desired mutation(s) on the protein structure, enabling structure browsing and generation of high-definition structural visualizations.SiMPLOD是一款在线数据库，收录了目前已报道的LH/PLOD（前胶原-赖氨酸2-氧戊二酸5-双加氧酶/赖氨酰羟化酶，Procollagen-Lysine 2-Oxoglutarate 5-Dioxygenase/Lysyl-Hydroxylase）的所有天然变异体与生化突变体。该数据库的交互界面支持在蛋白质结构上定位目标突变位点，可实现结构浏览并生成高清的结构可视化图像。

搜集汇总

背景与挑战

背景概述

SiMPLOD是一个手动策划的在线数据库，专门收集PLOD酶家族的自然变异和生化突变，并将其映射到可用的分子结构信息上。该数据库界面支持用户定位突变在蛋白质结构上的位置，实现结构浏览和生成高清可视化，适用于非专业用户。