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Targeting immunosuppressive myeloid cells and exhausted CD8 T cells overcomes radioresistance. Mus musculus

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NIAID Data Ecosystem2026-05-01 收录
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To elucidate the dynamic tumor immune microenvironment (TIME) changes after radiotherapy (RT), we performed droplet-based 5' scRNA-seq and paired scTCR-seq on CD45+ immune cells in the LLC-OVA model in three groups: control group (10 days after inoculation), RT-04 group (14 days after inoculation, 4 days after RT) and RT-10 group (20 days after inoculation, 10 days after RT). Mice received RT (20Gy) at day 10 after the tumor challenge.

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2023-12-26
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