DNA methylation in sex chromosomes and genes under selection underpins the emergence of sexual size dimorphism. Cynoglossus semilaevis

Here, we used a species with female-biased SSD, the Chinese tongue sole (Cynoglossus semilaevis), as a model to investigate the role of DNA methylation in the emergence and regulation of SSD. Methylomes and transcriptomes were constructed in four tissues (brain, liver, muscle and gonad) from three key life stages: juveniles (3-months post fertilization), male mature stage (1-year post fertilization; ypf), and female mature stage (3 ypf).