Figure S1 - Anthrax Lethal Toxin Suppresses Murine Cardiomyocyte Contractile Function and Intracellular Ca²⁺ Handling via a NADPH Oxidase-Dependent Mechanism

Effect of in vivo lethal toxin (LeTx) exposure on the expression of Bcl-xL, Bcl-2, Bax, Bad, cytochrome C and caspase-12 in murine hearts. Adult male C57BL/6J mice were treated with LeTx (2 µg/g b.w., i.p.) for 18 hrs. A: Representative gel blots of Bcl-xL, Bcl-2, Bax, Bad, cytochrome C, caspase-12 and α-tubulin (loading control) using specific antibodies; B: Bcl-xL; C: Bcl-2; D: Bax; E: Bad; F: Cytochrome C; and G: Caspase-12. Mean ± SEM, n = 4 –5 mice, * p<0.05 vs. C57BL/6J group without LeTX treatment. (0.20 MB DOC)