Supporting data for "The Assembled and Annotated Genome of the Masked Palm Civet (Paguma larvata)"

The masked palm civet (<i>Paguma larvata</i>) acts as an intermediate host of severe acute respiratory syndrome coronavirus (SARS-CoV), which causes SARS, and transfers this virus from bats to humans. Additionally, <i>Paguma larvata</i> has the potential to carry a variety of zoonotic viruses that may threaten human health. However, genome resources for <i>Paguma larvata</i> have not been reported to date. <br>A chromosome-level genome assembly of <i>Paguma larvata</i> was generated using PacBio sequencing, Illumina sequencing, and Hi-C technology. The genome assembly was 2.44 Gb in size, of which 95.32% could be grouped into 22 pseudochromosomes, with contig N50 and scaffold N50 values of 12.97 Mb, respectively. A total of 21,582 protein-coding genes were predicted, and 95.20% of the predicted genes were functionally annotated. Phylogenetic analysis of 19 animal species confirmed the close genetic relationship between <i>P. larvata</i> and species belong to the Felidae family. Gene family clustering revealed 119 unique, 362 significantly expanded, and 58 significantly contracted genes in the <i>P. larvata</i> genome. We identified 971 positively selected genes in <i>P. larvata</i>, and one known human viral receptor gene PDGFRA is positively selected in <i>P. larvata</i>, which is required for human cytomegalovirus (HCMV) infection.<br> This high-quality genome assembly provides a valuable genomic resource for exploring virus-host interactions. It will also provide a reliable reference for studying the genetic bases of the morphological characteristics, adaptive evolution, and evolutionary history of this species.