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Interplay of host microbiota, genetic perturbations, and inflammation promote local development of intestinal neoplasms in mice
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2019-05-14
相关数据集
AP4 regulates stem and Paneth cell homeostasis and promotes adenoma initiation in the intestine (small intestinal organoid)
AP4 is frequently expressed in primary CRCs. However, the in vivo relevance of AP4 for development of intestinal tumor formation has not been analyzed by genetic approaches. ApcMin/+ mice with deletio
NIAID Data Ecosystem50
Interplay of host microbiota, genetic perturbations, and inflammation promotes local development of intestinal neoplasms in mice [RNA-Seq]
The preferential localization of some neoplasms, such as serrated polyps, in specific areas of the intestine suggests that non-genetic factors may be important for their development. To test this hypo
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RNA sequencing i-Apc i-Mcl-1 murine intestinal organoids vs i-Apc controls
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An EphB-Abl signaling pathway important for intestinal tumor initiation and growth. Mus musculus
EphB receptors regulate the proliferation and positioning of intestinal stem and progenitor cells. In addition, they can act as tumor promoters for adenoma development, but suppress progression to inv
NIAID Data Ecosystem40
