Therapeutic effects of EGCG in experimentally induced ulcerative colitis in rats via affecting inflammation and apoptosis

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that affects the colon. Epigallocatechin gallate (EGCG), a compound found in green tea with antioxidant and anti-inflammatory properties. We aimed to investigate the impact of EGCG on inflammation and apoptotic pathways in UC rats. The study involved inducing UC in rats by administering acetic acid. The UC rats were then treated with EGCG. Colon samples were collected, measured then used to evaluate gene and protein expression of various factors, including NF-κB, TNF-α, SphK, MIP-1α, BCL2, and BAX, as well as the activities of caspase-3/8/9., Animals and treatment outlines
In this study, 36 rats belonging to the Sprague-Dawley species and weighing between 180 and 200 grams were employed. The rats were divided into three groups, each consisting of twelve rats.
Control group: Rats were subjected to mild anesthesia using ether followed by the administration of 2 ml of saline solution into the colon using a soft pediatric lubricated catheter. The rats were positioned horizontally for two minutes to prevent the saline from draining. Subsequently, they received a daily oral dose of 0.5% (w/v) methylcellulose and 2% (v/v) Tween 80, both dissolved in deionized water, for two weeks.
Ucerative Colitis group: The rats were anesthetized with ether and subsequently administered 2 ml of 4% acetic acid via a gentle pediatric catheter into their colon. Following the administration, the rats were positioned horizontally for two minutes to promote the retention of the acetic acid.
Ulcerative Colitis group treated with genistein: UC was induce..., , # Therapeutic effects of EGCG in experimentally induced ulcerative colitis in rats via affecting inflammation and apoptosis

[https://doi.org/10.5061/dryad.n02v6wx6v](https://doi.org/10.5061/dryad.n02v6wx6v)

## Description of the data and file structure

The uploaded data represented the experiment's results on colons separated from different rat groups used. The data are described in the following table: 

| Variable | Unit | Description |
| :---------------------- | :------------------ | :-------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |
| Group |   | The name of the group. The study consists of three groups: the control group, the ulcerativ...