A genome-wide screening identified effector genes of chromatin accessibility. To investigate the functional consequences of the loss of each effector gene, we conducted Mnase-seq with eHAP cells knock

NIAID Data Ecosystem30

BAHD1 couples H3K27me3 to gene silencing via a conserved BAH reader module and associated corepressor complex in mammals (RNA-Seq)

表观遗传调控

H3K27me3

Trimethylation of histone H3 lysine 27 (H3K27me3) is crucially involved for gene silencing, (epi)genome organization, cell-fate decision-making and development. To date, functional readout of H3K27me3

NIAID Data Ecosystem10

Chromatin accessibility analysis of induced trophoblast stem cells.

诱导滋养干细胞

染色质可及性分析

We report chromatin accessibility time-course profiling (ATAC-seq) of induced trophoblast stem cells (iTSCs) derived directly from human fibroblasts and naÃ¯ve reprogramming intermediates. Overall des

NIAID Data Ecosystem40

SCNT embryos are defective for H3K27me3 imprinting

体细胞核移植表观遗传

H3K27me3

Animal cloning can be achieved through somatic cell nuclear transfer (SCNT), yet the success rate remains very low. Recent studies have revealed two epigenetic barriers, H3K9me3 in donor cells and abn

NIAID Data Ecosystem20

CBS513.88wt_DPY_H3K27me3

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