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Eradicating neuroblastomas by an RBM39 degrader in combination with anti-GD2 immunotherapy regardless of cancer cell state alterations

NIAID Data Ecosystem2026-05-02 收录

神经母细胞瘤联合治疗

RBM39降解剂-抗GD2免疫疗法

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE251920 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2025-06-06

神经母细胞瘤联合治疗

表观遗传与分化疗法

Neuroblastoma is a pediatric cancer characterized by variable outcomes ranging from spontaneous regression to life-threatening progression. High-risk neuroblastoma patients receive myeloablative chemo

NIAID Data Ecosystem30

Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors

神经母细胞瘤联合治疗

MEK抑制剂耐药机制

Aberrant RAS/MAPK signaling, a common driver of oncogenesis, can be therapeutically targeted with clinically approved MEK inhibitors. Single agent therapy ultimately results in tumor outgrowth in most

NIAID Data Ecosystem30

Photosensitive composite nanoparticles adsorbing p-sh BLM for the synergistic therapy of neuroblastoma

神经母细胞瘤联合治疗

光动力-基因协同疗法

Photodynamic therapy (PDT) represents a promising noninvasive modality for the selective targeting of tumors. However, its clinical utility is often constrained by the aggregation-induced quenching of

NIAID Data Ecosystem20

Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppression [RNA-Seq]

神经母细胞瘤联合治疗

表观遗传-分化治疗机制

NIAID Data Ecosystem30

Inhibition of mitochondrial translocase SLC25A5 and histone deacetylation is an effective combination therapy in neuroblastoma

神经母细胞瘤联合治疗

药物转录组学

Mitochondria are gatekeepers of apoptotic processes and mediate drug resistance to several chemotherapy agents used to treat cancer. Neuroblastoma is a common solid cancer in young children with poor

NIAID Data Ecosystem20

Eradicating neuroblastomas by an RBM39 degrader in combination with anti-GD2 immunotherapy regardless of cancer cell state alterations

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