The impact of HTLV-1 expression on the 3D structure and expression of host chromatin

We used cultured clones of HTLV-1-infected cells, each with a single HTLV-1 provirus integrated at a known position. We used flow-cytometry to sort cells to those actively transcribing the viral transactivator Tax (or marker thereof, GFP) and those which are not. We report chromatin contacts (using q4C-seq) and RNA expression in the sorted fractions, each fraction in two replicates.