Game centrality of party hubs, date hubs and randomly selected nodes of a high-fidelity yeast protein-protein interaction network.

aPrisoner’s dilemma game was simulated using the high-fidelity yeast interactome of Ekman et al.[36], and game centrality measures were calculated as described in Methods.
bInitially all 2,444 nodes were cooperating except for 30 defecting nodes, which were randomly sampled 2000 times from 63 consensus party hubs (compiled as in [43], see Table S1 of Text S1), from 145 consensus date hubs (compiled as in [43], see Table S2 of Text S1), as well as from all the 2,444 nodes in the network.
cData represent sample means ± standard error. The distributions of the game centrality values were significantly different according to the chi-square test (χ2>400).