Effect of extracellular pH on drug response (Fig 6A and S9 Fig).

Parasites were exposed to increasing levels of CQ or DHA for 72 h or PPQ for 84 h in acidic (pH = 6.74), normal (pH = 7.5) or basic (pH = 8.24) media. Included are the EC50 or AUC data for four biologically independent experiments run in triplicates for Dd2, 3D7, KH001_053G10, KH001_053G8, and KH004_057 including the average and SD of the AUC or EC50. Unpaired Student’s t-test between pH at 7.5 and lower or higher pH if more than three values could be determined: **p < 0.01, ***p < 0.001.
(XLSX)