ChIP-seq analysis of HIF and AR binding sites in LNCaP cell line. ChIP-seq analysis of HIF and AR binding sites in LNCaP cell line

Androgen receptor (AR) and hypoxia inducible factor 1a (HIF1a) are transcription factors that promote prostate cancer progression. This study investigated the relationship between the AR and HIF1a signaling pathways. ChIP-seq analysis was performed on the LNCaP cell line to identify global HIF and AR binding sites within the genome, under hypoxia and normoxia and in the presence and absence of androgen treatment. Overall design: 16 samples analyzed