Thymidylate synthase polymorphisms and methotrexate therapeutic outcome.

Results are expressed in n (%). p value§Fisher's exact test used when number of cases of one cell was less than 5.¥Statistically significant when p values were adjusted for multiple comparisons correction using Bonferroni's method (α = 0.05/n comparisons).#3R4R genotype (n = 4) was excluded from analyses due to the low frequency.*rs2853542 - TYMS SNP C>G on 3R allele.**Genotypes theoretically associated with TS expression: a) high: 3RG3RG; b) median: 2R3RG and 3RC3RG; c) low: 2R2R, 2R3RC and 3RC3RC.bp: base pairs; C: cytosine; del: deletion; G: guanine; OR: odds ratio; R: repeat; SNP: single nucleotide polymorphism; TS: thymidylate synthase (protein); TSER: TYMS enhancer region; TYMS: thymidylate synthase (gene); VNTR: variable number tandem repeat.Thymidylate synthase polymorphisms and methotrexate therapeutic outcome.