Supplementary data for the publication: “Burdens of digestive-related psychosomatic diseases from 1990 to 2021 and projection to 2030 in China: Findings from the 2021 Global Burden of Disease Study”

<strong>Background</strong>Digestive-related psychosomatic disorders (PSDs) pose substantial socio-economic and healthcare burdens in China. This study analyzed trends from 1990 to 2021 for common digestive-related PSDs—namely inflammatory bowel disease (IBD), peptic ulcer disease (PUD), anorexia nervosa (AN), bulimia nervosa (BN), and gastroesophageal reflux disease (GERD)—and projected their burden through 2030 to inform prevention and management.<strong>Methods</strong>Data on incidence, prevalence, mortality, and disability-adjusted life years (DALYs) for the five PSDs were extracted from the Global Burden of Disease Study 2021. Age-standardized rates for prevalence (ASPR), incidence (ASIR), mortality (ASMR), and DALYs (ASDR) were calculated. The Bayesian age-period-cohort (BAPC) model was applied to forecast trends up to 2030.<strong>Results</strong>In 2021, ASDRs per 100,000 population were 43.79 for PUD, 7.68 for IBD, 7.42 for AN, 22.18 for BN, and 35.12 for GERD. Projections indicate stable ASIR and ASPR for PUD and IBD, with declines in ASMR and ASDR. AN and GERD metrics are expected to remain stable, while BN shows an increasing trend across all indicators, suggesting a rising disease burden.<strong>Conclusion</strong>Digestive-related PSDs remain a significant health challenge in China. Advances have reduced PUD’s impact, but other conditions require strengthened multidisciplinary management. Enhanced government and health system strategies are critical to mitigate the social and economic impacts of these disorders.

**背景** 消化系统相关心身障碍（Digestive-related psychosomatic disorders, PSDs）在中国造成了沉重的社会经济与医疗卫生负担。本研究分析了1990年至2021年间常见消化系统相关心身障碍的流行趋势，具体包括炎症性肠病（inflammatory bowel disease, IBD）、消化性溃疡病（peptic ulcer disease, PUD）、神经性厌食症（anorexia nervosa, AN）、神经性贪食症（bulimia nervosa, BN）以及胃食管反流病（gastroesophageal reflux disease, GERD），并预测了至2030年的疾病负担，以期为疾病防控与临床管理提供参考依据。
**方法** 本研究从2021年全球疾病负担研究（Global Burden of Disease Study 2021）中提取了上述5种心身障碍的发病率、患病率、死亡率与伤残调整生命年（disability-adjusted life years, DALYs）相关数据；计算了患病率年龄标化率（ASPR）、发病率年龄标化率（ASIR）、死亡率年龄标化率（ASMR）以及伤残调整生命年年龄标化率（ASDR）；采用贝叶斯年龄-时期-队列（Bayesian age-period-cohort, BAPC）模型对截至2030年的疾病趋势进行预测。
**结果** 2021年，每10万人口的伤残调整生命年年龄标化率（ASDR）分别为：消化性溃疡病43.79、炎症性肠病7.68、神经性厌食症7.42、神经性贪食症22.18、胃食管反流病35.12。预测结果显示，消化性溃疡病与炎症性肠病的发病率年龄标化率（ASIR）与患病率年龄标化率（ASPR）保持稳定，死亡率年龄标化率（ASMR）与伤残调整生命年年龄标化率（ASDR）呈下降趋势；神经性厌食症与胃食管反流病的各项指标预计将维持稳定，而神经性贪食症的所有指标均呈上升趋势，提示其疾病负担将持续加重。
**结论** 消化系统相关心身障碍仍是中国面临的重大公共卫生挑战。现有防控进展已降低了消化性溃疡病的疾病影响，但其余病种仍需强化多学科管理。需进一步完善政府与医疗卫生系统的相关策略，以减轻此类疾病造成的社会与经济负担。