Misfolded proteins translocate from cilium to cytosol

Cellular stress factors damage several cilia proteins and result in their misfolding. These misfolded proteins are translocated into the cytosol of the cell where they are ubiquitinated and eliminated (Lam HC et al. 2013). Confirmatory experiments were performed in mice.

细胞应激因素损害了多种纤毛蛋白，导致其错误折叠。这些错误折叠的蛋白被转运至细胞质中，在那里它们被泛素化并被清除（Lam HC 等人，2013）。在老鼠身上进行了证实性实验。