ADHD Genomic Association Study

Studies at Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands, has recruited participants with ADHD and participants without ADHD, which included matched healthy controls and family members of participants with ADHD. ADHD participants met DSM-IV-TR criteria for ADHD. DNAs of these participants, 1005 samples, were anonymously genotyped with Illumina PsychArray. These samples were not part of the PGC-ADHD group. After removing family members, 820 case/control independent samples, including 211 ADHD cases, went through genomic association analyses. Results of ADHD risk genetic markers were compared with genetic markers associated with brain structure alterations in ADHD in adults and adolescents.]]>
This study started from a cohort of 1001 participants from Netherlands, including participants with ADHD, relatives and healthy controls. Genome wide SNP information was assessed using Illumina PsychArray. To compute SNP risk information for ADHD, we removed 206 relatives, and one participant whose genetic profile indicates non-Caucasian. The genetic association results presented are from a logistic regression with 4 population stratification factors from MDS on 794 participants (442 males, 352 females).Samples were collected from previous studies, and used as secondary analysis purpose. No further exclusion was applied.]]>