The weights of PRS for idiopathic pulmonary arterial hypertension

This study aimed to develop a comprehensive prediction model integrating
polygenic risk scores (PRS) and clinical factors to identify individuals
at high risk for incident idiopathic pulmonary arterial hypertension
(IPAH). A PRS was constructed using summary statistics derived
from the largest genome-wide association study for pulmonary arterial
hypertension in Europeans and validated in the UK Biobank (732 cases,
458,258 controls). After excluding individuals with IPAH at baseline,
316,073 participants (316 incident IPAH patients) were split into training
and testing sets (7:3). Variable selection was performed using least
absolute shrinkage and selection operator in the training set, and a
prediction model for incident IPAH was established using the Cox
proportional hazards model. The dataset here is the Supplementary
Data for the manuscript titled "Polygenic risk score and clinical
factors predict incident idiopathic pulmonary arterial hypertension".
The dataset contains the weight for each single-nucleotide polymorphism
used for constructing PRS for IPAH.