Copper Catalyzed C–N Cross-Coupling Reaction of Aryl Boronic Acids at Room Temperature through Chelation Assistance

A copper-catalyzed
selective C–N cross-coupling has been
developed based on chelation-assisted amidation of readily available
aryl boronic acids at room-temperature under open-flask conditions.
The reaction is scalable and tolerates a wide spectrum of functional
groups delivering fully substituted unsymmetrical amides in high yields
(up to 96%). The C–N cross coupling also established with aryl
silanes, extending the palette of coupling partners of this strategy.