Tryptamine induced metabolic alterations of prostate cancer in vitro and in vivo

Tryptamine is the most important compound of the indoleamine family, and its scaffold has been applied in the design of pharmacological agents with anti-migraine, antibacterial and antitumor effects . tryptamine had a stronger inhibitory effect on high metastatic PCa cell line PC-3 and low metastatic PCa cell line LNCaP compared to the normal prostate epithelial cell line RWPE-1. It also shown to induce cell apoptosis and could markedly inhibit cell migration of PC-3.Metabolic changes induced by tryptamine treatment of PC-3 cells and tumor xenograft mice were also analyzed, with differential metabolites involved in amino acid metabolism and related to prostate cancer development and metastasis identified.