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modzs.gctx: a legacy LINCS L1000 dataset of differential expression signatures

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Figshare2016-08-29 更新2026-04-29 收录
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https://figshare.com/articles/dataset/modzs_gctx_a_legacy_LINCS_L1000_dataset_of_differential_expression_signatures/3759129
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modzs.gctx contains a probe (rows) × signature (columns) matrix of differential expression z-scores from the LINCS L1000 project. The file uses a compressed binary encoding that can be read using the `cmap/l1ktools` drivers.modzs.gctx is an input for the dhimmel/lincs repository, but is too large to be uploaded to GitHub. dhimmel/lincs extracts signatures from modzs.gctx to compute consensus signatures for perturbagens. Consensus signatures from dhimmel/lincs are available at https://doi.org/bp22 as user-friendly TSV files. modzs.gctx is uploaded for reproducibility of dhimmel/lincs and longterm preservation. Users who need raw LINCS L1000 data are encouraged to use the Broad Production Data hosted on GEO rather than the legacy modzs.gctx file.I (Daniel Himmelstein) originally retrieved modzs.gctx from the following path on the L1000 C3 Cloud (c3.lincscloud.org): /xchip/cogs/data/build/a2y13q1/modzs.gctx. However, the original hosting is no longer operating. Therefore, I am uploading this file to figshare.I am choosing a CC BY license with the requirement to attribute the LINCS L1000 Team at the Broad Institute. However, users should note that the licensing of modzs.gctx is murky. The Broad license (https://git.io/vieCF) states that data files cannot be redistributed, which conflicts the NIH LINCS Data Release Policy. See https://doi.org/bfmn for more information.
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2016-08-29
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