Identification of the circadian clock genes as components of the compensatory mechanism in nphp8 mutant zebrafish. Identification of the circadian clock genes as components of the compensatory mechanism in nphp8 mutant zebrafish

The nphp8sa24730 mutant zebrafish displayed a marked decrease in glomerular cysts and cloaca malformation over subsequent generations, implying the existence and activation of compensatory mechanisms that could rescue the ciliopathy-associated phenotypes. To uncover these mechanisms, we compared the transcriptional profiles of two-day-old maternal zygotic homozygous nphp8sa24730 mutant larvae and control siblings by RNA sequencing (RNA-seq). Overall design: Comparative gene expression profiling analysis of RNA-seq data for two-day-old maternal zygotic homozygous nphp8(sa24730) mutant zebrafish larvae and control siblings.