Cryo-EM structure of holo-PdxR from Bacillus clausii bound to its target DNA in the closed conformation, C2 symmetry.

Cryo-EM structure of holo-PdxR from Bacillus clausii bound to its target DNA in the closed conformation, C2 symmetry. Descriptor: DNA (48-MER), PLP-dependent aminotransferase family protein Authors: Freda, I, Montemiglio, L.C, Tramonti, A, Contestabile, R, Vallone, B, Exertier, C, Savino, C, Chaves Sanjuan, A, Bolognesi, M. Deposit date: 2022-04-20 Release date: 2023-07-05 Last modified: 2024-01-17 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural insights into the DNA recognition mechanism by the bacterial transcription factor PdxR. Nucleic Acids Res., 51, 2023

克劳氏芽孢杆菌（Bacillus clausii）来源的全酶型PdxR（holo-PdxR）结合靶DNA且处于闭合构象、具有C2对称性的冷冻电子显微镜（Cryo-Electron Microscopy, Cryo-EM）结构。描述项：DNA（48聚体）、磷酸吡哆醛（Pyridoxal 5'-phosphate, PLP）依赖型氨基转移酶家族蛋白。作者：Freda, I、Montemiglio, L.C、Tramonti, A、Contestabile, R、Vallone, B、Exertier, C、Savino, C、Chaves Sanjuan, A、Bolognesi, M。存档日期：2022年4月20日；发布日期：2023年7月5日；最后更新日期：2024年1月17日。实验方法：电子显微镜（分辨率3.7埃）。引用文献：《细菌转录因子PdxR识别DNA机制的结构学见解》，《核酸研究（Nucleic Acids Research）》，第51卷，2023年。