Domino Assembly of Trifluoromethylated N,O-Heterocycles by the Reaction of Fluorinated α‑Bromoenones with Amino Alcohols
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https://figshare.com/articles/dataset/Domino_Assembly_of_Trifluoromethylated_N_O-Heterocycles_by_the_Reaction_of_Fluorinated_Bromoenones_with_Amino_Alcohols/3979434
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资源简介：
A highly efficient
method for the selective synthesis of trifluoromethylated
morpholines (4-oxa-1-azabicyclo[4.1.0]heptanes) and so far unknown
1,4-oxazepanes (2,8-dioxa-5-azabicyclo[5.1.0]octanes) based on a domino
reaction of fluorinated α-bromoenones with β-amino alcohols
was elaborated. The assembly of both heterocyclic systems is initiated
by an aza-Michael reaction followed by intramolecular cyclization.
The conditions for total control of selectivity of the reaction were
found.
创建时间：
2016-10-28
