The effect of marine-derived n-3 PUFAs supplementation on CRP, IL-6 and TNF-α in subjects with chronic no-autoimmune disease (data were log-transformed before analysis).

N, number of included studies (or comparisons); NA, not associated with this item; CVD, cardiovascular disease.
Subjects with high risk of CVD included overweight (or obese) subjects, subjects with dislipidemia, subjects with diabetes, and subjects with metabolic syndrome; subjects in the study by Mocking et al. in 2012 were diagnosed with both diabetes mellitus and depression simulaneously, so this study was included in both subgroup “presence or high risk of CVD” and subgroup “psychiatric disease” without calculating the overall effect size for all the studies.
Unit for CRP: mg/L; unit for IL-6 and TNF-α: pg/mL.
Data expressed in bold indicated that subgroup difference was significant (P for subgroup difference <0.05), and subgroup “not reported” was not included in the significance test for subgroup difference.